EP1.14-23 Comparison of Molecular Testing Using Various Specimens for Non-Small Cell Lung Cancers
نویسندگان
چکیده
منابع مشابه
molecular Diagnostic testing in Non-small Cell Lung Cancer
Introduction Over the past decade, the oncology community has witnessed a revolution in our understanding of the biology of lung cancer with the identification of a significant proportion of patients whose tumors harbor targetable molecular changes. these recurrent genomic alterations include mutations, gene rearrangements, and copy number changes in relevant lung cancer genes (Figure 1). A var...
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Targeted therapies guided by molecular diagnostics have become a standard treatment of lung cancer. Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are currently used as the best predictive biomarkers for EGFR tyrosine kinase inhibitors and ALK inhibitors, respectively. Besides EGFR and ALK, the list of druggable genetic alterations has been...
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AIM To conduct a methods correlation study of three different assays for the detection of mutations at EGFR gene in human formalin-fixed paraffin-embedded tumour (FFPET) specimens of non-small cell lung carcinomas (NSCLC). METHODS We conducted a 2-site method comparison study of two european conformity (CE) in vitro diagnostic (IVD)-marked assays, the cobas EGFR Mutation Test and the Therascr...
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BACKGROUND Single tumors may show heterogeneity, and it is unclear whether biomarker expression in surgical and diagnostic biopsy samples correlates. MATERIALS AND METHODS We retrospectively identified lung cancer patients who were diagnosed by biopsy and underwent surgery between January 2007 and October 2010 at the Shimane University Hospital, Shimane, Japan. Thirty-two patients were identi...
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About 40% of patients with non-small-cell lung cancer (NSCLC) present with stage IV disease, while resectable early stages I–II and marginally resectable locally advanced stage III each represent one-third of the patients, respectively. The anatomical surgical landmark has been paradigmatically established by the international staging system between stages IIIA and IIIB [1]. Clearly, this front...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2019
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2019.08.2308